Event № 512
A common mechanism for intramembrane cavitation bioeffects is presented and possible bioeffects, both delicate and reversible or destructive and irreversible, are discussed. Two conditions are required for creating intramembrane cavitation in a bi-layer sonophore (BLS) in vivo: low peak pressure of a pressure wave and an elastic wave of liquid removal from its surroundings. Such elastic waves may be generated by a shock wave, by motion of a free surface, by radiation pressure, by a moving beam of focused ultrasound or any other source of localized distortion of the elastic structure. Soft, cell laden tissues such as the liver, brain and the lung, are more susceptible to irreversible damage. Here, we show the similarity between ultrasound, explosion and impact, where the driving force is negative pressure, and decompression, induced by imbalance of gas concentration. Based on this unified mechanism, one can develop a set of safety criteria for cases where the above driving forces act separately or in tandem, (e.g., ultrasound and decompression). Supporting histological evidence is provided to show locations prone to IMC-related damage; where the damaging forces are relatively high and the localized mechanical strength is relatively poor.